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Emepelle Night Cream

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Emepelle Night Cream is a luxurious and restorative cream that harnesses skin’s nighttime repair activities to help restore vitality and luminosity to aging skin.  This rich and nourishing night cream features breakthrough MEP Technology to help restore the natural function of Estrogen Deficient Skin non-hormonally, for improved firmness, hydration and luminosity.  Emepelle Night Cream is designed specifically for women in menopause and perimenopause.

  • Targets the root cause of Estrogen Deficient Skin non-hormonally, with exclusive MEP Technology
  • Also includes retinol, niacinamide and peptides for additional anti-aging benefits
  • Features emollients and humectants, such as Shea Butter, Grape Seed Oil and Hyaluronic Acid, to leave skin feeling hydrated, soft and supple
  • Clinically proven results
  • Gluten-free, paraben-free
SKU: NIGHT48EME Product Types: , , Skincare Concerns: ,

Related Skincare Concerns

  • Estrogen Deficient Skin
  • Dry or aging skin
  • Dull skin
  • Sagging skin

Clinical Results

Emepelle is clinically proven2 to help address accelerated collagen loss and skin aging due to Estrogen Deficient Skin. In a clinical study using Emepelle Serum and Emepelle Night Cream for 8 weeks:

  • 100% of study participants showed improvement in skin hydration
  • 93% of study participants agreed that Emepelle improved the appearance of their skin
  • 64% of study participants saw a reduction in wrinkles

Size: 1.7 oz

Key Ingredients

MEP Technology® – Helps address the root cause of Estrogen Deficient Skin, non-hormonally to revitalize skin’s natural source of radiance
Retinol – Helps reduce the appearance of wrinkles and hyperpigmentation, decrease skin roughness and aid in nightly rejuvenation
Niacinamide — Helps brighten and even skin tone, improve texture, smooth the appearance of fine lines and wrinkles and provide additional antioxidant protection
Peptides –  Helps combat oxidative stress and improve the appearance of fine lines, wrinkles and skin laxity
Hyaluronic Acid — Helps improve hydrations and supports the skin’s moisture barrier
Emollients and Humectants – Including Shea Butter, Grape Seed Oil and Apricot Kernel Oil. Helps to hydrate the skin and replenish skin’s moisture barrier

Show Full Ingredient List

How to Use

Apply nightly to cleansed, dry skin. If you have not previously used retinol, it is recommended to begin using Emepelle Night Cream two to three nights per week and to slowly increase usage as your skin tolerates. For optimal results, use Emepelle Serum in the morning and Emepelle Night Cream in the evening.



8 Weeks Later



  1. Uma

    I have to say this magical potion is remarkable. I know it may be a little early in my regimen with this product to leave such a review but as a 46 year old truly I see a difference in my skin already in one week of use. I know collagen and fibroblasts take longer to regenerate so I am just so excited to see the further improvements I know are going to happen with this product, because they are already happening. I did have a bit of a reaction and irritation at first, this is really full of so many actives that my skin just went a little crazy. I backed off for 2 days and super hydrated my skin barrier and stopped all the other actives and AHAs/BHAs I was using then started back with it because i just really wanted to keep trying with the product and first used a moisturizer first before adding a little bit of emepelle back little by little over the past 3 nights now I’m up to just the pure emepelle night moisturizer on my face and neck on my clean dry skin and having no problems now with it, its a dream. And have also been working my way up with the serum as well in the mornings over the same time period in a similar fashion with that, slowly introducing both. My skin actually does have more hydration with in it, more snap back in that little area of loose skin under my chin and jaw. The emepelle went to work on me right away and I peeled like crazy the first 4 days and now I have this completely refreshed and revitalized skin happening and am tolerating the night cream and the serum in the day without any reaction or irritations. And its not just how my face looks when I look in the mirror, I feel it. It’s amazing. My face skin feels like more adhered to my actual face. As though I don’t feel like gravity is pulling my face down or like my face is sinking down into my neck like what I know I was feeling a week ago. It’s just different, I feel my skin is different, it is unbelievable but its really true and happening. This product is remarkable and any woman in her late 30’s should start using these products because that’s when the estrogen is starting to decrease every so slowly and the collagen and elastin are decreasing progressively each year. I would have started this in my late 30’s already if this had been around and I had known how much collagen I was going to be loosing by my mid 40’s when I could have retained so much more of what I have lost in my skin already. But Im starting now so I am thrilled to have learned about this product and to have have access to such a new science. If Emepelle would please make a body product for the body I will definitely be using this game changer with Emepelle and MEP from head to toe. I will be the first in line for a body product from Emepelle to add to my treatment protocol here. Emepelle, you have a costumer for life.

MEP Technology

For Estrogen Deficient Skin

Breakthrough MEP Technology does what other anti-aging products are simply not able to do. MEP helps address a root cause of accelerated skin aging in Estrogen Deficient Skin to restore its natural function, non-hormonally.

MEP is clinically proven to safely and effectively help improve dryness, dullness, laxity, atrophy and the appearance of fine lines for more healthy, youthful-looking skin.

Learn more about MEP Technology

MEP Technology

Learn more about MEP Technology




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(vs 16% improvement with placebo)


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(vs 8% improvement with placebo)


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(vs 6% improvement with placebo)

Frequently Asked Questions

While Emepelle Night Cream is suitable for all skin types, it does contain retinol which may cause irritation for some skin.  Anytime you try a new product it’s recommended that you start with a patch test and monitor for any adverse reactions. 

In clinical studies, Emepelle made a marked improvement in users’ skin after only eight weeks of use, though the timeframe of results may vary.  

Emepelle Night Cream works to improve skin’s health and appearance, including improved firmness, luminosity and hydration while you sleep. 

Estrogen Deficient Skin occurs in women who are perimenopausal and menopausal as estrogen levels throughout the body decline.  The impact to the skin is noticeable dryness, dullness, sagging, thinning, fine lines and/or wrinkling. If you feel like you have perpetually dehydrated skin, or like your skin has lost its luminosity or youthful “glow”,  you may be experiencing Estrogen Deficient Skin.

No. Emepelle Night Cream is a non-hormonal treatment that helps restore skin texture, firmness, hydration and luminosity. Emepelle Night Cream is completely non-hormonal and has benefits exclusively on the skin.  

Emepelle is intended for individuals with Estrogen Deficient Skin, which occurs during perimenopause and menopause. However, Emepelle Night Cream contains other active ingredients such as niacinamide, peptides, antioxidants and retinols that benefit skin of all ages. 

Emepelle is non-hormonal. MEP Technology has been clinically proven to be safe though it has not been tested on individuals with specific medical conditions. Please consult your doctor with any questions.

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