Non-Hormonal Alternatives to Estrogen Face Creams

Fresh face image of woman outdoors

Estrogen is a collection of hormones that plays an important role in skin health and helping to promote smooth, plump and firm-looking skin. It helps boost collagen, elastin and hyaluronic acid production in skin to keep it looking healthy. Unfortunately, this hormone naturally declines over time. 

As a result, skin can begin to show common signs of aging such as thinner skin, increased dryness and fine lines and wrinkles. Learn about effective non-hormonal skincare alternatives that address these skin issues and more.

Antiquated Estrogen Creams for the Face 

Women have long sought skincare products to help them achieve a more youthful appearance at any age, and for decades, the link between estrogen and skin health has been well understood. In fact, eighty years ago, skin creams with estrogen emerged touting promises of renewed facial beauty. 

At that time, hormonal estrogen face cream wasn’t regulated, and since then, concerns have risen about the connection between products containing estrogen and cancer

Today’s Non-Hormonal Skincare Solutions

Today, there are  a plethora of products to help women address the impact of declining estrogen, but only one ingredient is clinically proven to help restore the skin’s natural function without hormones and, therefore, without the risks of topical estrogen: Methyl Estraodiolpropanoate, or MEP.

Learn more about the restorative power of MEP and other ingredients that can help reduce the signs of aging in skin below.

MEP Technology®

Methyl Estraodiolpropanoate (MEP) is a breakthrough ingredient that acts as a non-hormonal estrogen receptor aide (NERA) to the skin. 

MEP Technology interacts with the body’s natural estrogen receptors to help stimulate collagen and elastin production. MEP Technology is clinically proven to help restore the natural function of Estrogen Deficient Skin completely non-hormonally, and it is clinically proven to be safe and effective.   

 While there are many skincare ingredients that help address the impact of estrogen loss on skin health, MEP is the only ingredient that addresses the root cause to help prevent accelerated skin aging before it occurs. This powerful skincare technology can be used by women in perimenopause or menopause to help mitigate the signs of aging associated with Estrogen Deficient Skin.

Clinically proven results

After 14 weeks of MEP application in a clinical study, participants reported:

  • 54% improvement in dryness
  • 39% improvement in skin dullness
  • 19% improvement in laxity

MEP Technology is formulated to target fine lines and wrinkles, dryness and dullness and skin laxity, resulting in:

  • Smoother, Healthier-looking skin
  • Improved hydration and luminosity
  • Improved skin firmness

MEP Technology is exclusively available in the Emepelle skincare line.


Niacinamide is a form of Vitamin B3 that can help improve the appearance of aging skin. When applied topically in skincare, niacinamide can support healthy cell maintenance and help protect skin from free radical damage. It can also help make skin appear fresher and brighter.

Niacinamide can help restore the skin’s natural moisture barrier, which can help reverse the signs of aging. When skin retains moisture, it can:

  • Smooth out wrinkles
  • Improve skin’s surface structure 
  • Improve crepey skin
  • Reduce blotchiness, redness and inflammation

You can find niacinamide paired with MEP Technology in the Emepelle Serum and the Emepelle Night Cream.

Hyaluronic Acid

Dry, dull-looking skin can exacerbate the appearance of fine lines and wrinkles. Hyaluronic acid helps improve skin hydration and helps support the skin’s moisture barrier. According to the Cleveland Clinic, hyaluronic acid reduces skin wrinkles. It may also help reduce the appearance of scarring. 

Hyaluronic acid is a key ingredient in Emepelle Serum and Emepelle Night Cream. While the benefits of hyaluronic acids don’t specifically address EDS, perimenopausal and menopausal skin will benefit from the additional hydration benefits. 


Retinol is a topical form of retinoid derived from Vitamin A. It increases cellular turnover by helping older skin cells shed more quickly to reveal healthy-looking, brighter skin. Retinol is also effective at helping to promote collagen production, which can reduce the appearance of wrinkles and fine lines while promoting firmer, plumper-looking skin.

Retinol is an ingredient in Emepelle Night Cream that helps restore vitality and luminosity to Estrogen Deficient Skin.


Peptides are amino acids that play an integral role in skin proteins like elastin and collagen. Using peptides in skincare can help you achieve firmer and more youthful-looking skin, since they stimulate your skin to produce more collagen and elastin.

Because a drop in estrogen causes your skin to produce less collagen and elastin, supplementing with skincare containing peptides helps address Estrogen Deficient Skin. Peptides also protect the skin from oxidative stress that can lead to more fine lines and wrinkles. 

Peptides are in all Emepelle products, including Emepelle Eye Cream.

Prevent & Treat Estrogen Deficient Skin Effects With Emepelle

There are many skincare ingredients that help address the effects of estrogen loss on skin health. As discussed above, MEP is the only ingredient clinically proven to address the root cause and help prevent accelerated skin aging before it occurs.

So, whether you’re in perimenopause or menopause, or you want to proactively prevent skin issues caused by aging, Emepelle skincare can help you achieve and maintain a more luminous, healthy-looking appearance. 

Explore your options with the Emepelle Estrogen Deficient Skin Set, which includes the Emepelle Serum, Emepelle Night Cream and Emepelle Eye Cream for clinically-proven results and hormone-free alternative to estrogen face cream.